王真，beat365官方网站医药生物技术所研究员、博士生导师，生化室主任。1997年毕业于山东医科大学临床医学专业，获学士学位；2002毕业于中国协和医科大学微生物与生化药学，获博士学位。2002年至今在beat365官方网站医药生物技术研究所工作至今，2002-2004和2004-2006分别在新加坡基因组研究院和美国密西根大学做博士后研究。2011年9月起陆续任医药生物技术研究所研究员、博士生导师、生化室主任。2024年1月入选beat365官方网站准聘长聘系列助理教授。主持完成七项国家自然科学基金项目。作为主要贡献者曾获北京科技三等奖。

长期从事肿瘤和炎症代谢病的病理机制和相关药物药理研究，阐述了多个调控肿瘤转移、凋亡抵抗和周期进展的蛋白稳态新机制以及调节骨代谢稳态的新表观遗传机制；发现了多种抗肿瘤或抗骨质疏松药物的新作用机制。作为通讯或第一作者在Cell Death Differ, Cancer Lett, Cancer Res, Kidney Int, Oncogene, J Bone Miner Res, Faseb J等国际知名期刊发表SCI文章30余篇，其中多篇通讯作者文章超过100次引用。累计获引用2230余次，H指数27。以主要发明人获授权中国专利七项。

1. Zheng L#, Shen J#, Chen Y, Lin J, Li P, Zhao X, Ren H, Sun Y*, Wang Z*. FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2. Cancer Letters. 2024:591:216848. (IF=10.1)

2. Zhao X#, Lin S#, Ren H#, Sun S, Zheng L, Chen LF, Wang Z*. The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis. Cell Death and Differentiation 2024, 31(5):605-617. (IF=15.4)

3. Shen J#, Yang H#, Qiao X, Chen Y, Zheng L, Lin J, Lang J, Yu Q, Wang Z*. The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis. Cell Death and Differentiation 2023, 30(10): 2322-2335. (IF=13.7)

4. Qiao X#, Lin J#, Shen J, Chen Y, Zheng L, Ren H, Zhao X, Yang H, Li P, Wang Z*. FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation. Oncogene 2023, 42(39):2878-2891. (IF=8)

5. Li H#, Zhao X#, Zheng L, Wang X, Lin S, Shen J, Ren H, Li Y, Qiu Q, Wang Z*. Bruceine A protects against diabetic kidney disease via inhibiting galectin-1. Kidney International 2022, 102(3): 521-535. (IF=19.6)

6. Zhao X, Lin S, Li H, Si S*, Wang Z*. Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level. Journal of Bone and Mineral Research. 2021, 36(3):591-603.

7. Shen J, Zhan Y, Li H and Wang Z*, Ouabain impairs cancer metabolism and activates AMPK-Src signaling pathway in human cancer cell lines. Acta Pharmacologica Sinica, 2020 Jan;41(1):110-118.

8. Shen J, Li P, Shao X, Yang Y, Liu XJ, Feng M, Yu Q, Hu R*, Wang Z*. The E3 ligase RING1 targets p53 for degradation and promotes cancer cell proliferation and survival. Cancer Research 2018, 78(2):359-371. (IF=8.38)

9. Wang Y, Qiu Q, Shen J, Li D, Jiang X, Si S, Shao R*, Wang Z*. Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways. International Journal of Biochemistry & Cell Biology 2012, 44(11):1813-1824. (IF=4.15, C100)

10. Wang Z#, Zheng M#, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin CP, Zheng W, Xie Z, Sun Y*. Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Research 2009, 69(16): 6556-6564. (IF=7.53)